REFERENCES AND PROFESSIONAL EXPERTISE

  1. Maradonna F, Carnevali O. “Lipids as Target of Obesogens.” Chemosphere. 2018;192:658-667. Discusses how flavonoids counteract the adverse effects of obesogens on lipid metabolism and endocrine disruption.
  2. González-Gallego J, et al. “Flavonoids as antiobesity agents: Molecular mechanisms.” Current Medicinal Chemistry, 2016. Describes how flavonoids regulate metabolic pathways and reduce fat accumulation.
  3. Yang CS, et al. “Bioavailability issues in studying the health effects of plant polyphenolic compounds.” Molecular Nutrition & Food Research. 2019. Highlights bioavailability and specific effects of flavonoids like quercetin, fisetin, and luteolin.
  4. Lauten SD, et al. “Evaluation of weight loss in dogs fed a low-fat high-fiber diet with and without supplemental flavonoids.” Journal of the American Veterinary Medical Association. 2006. Flavonoid-supplemented diets resulted in greater reductions in body weight and inflammation in overweight dogs.
  5. Heindel JJ, et al. “Metabolism disrupting chemicals and metabolic disorders.” Reproductive Toxicology, 2017. Defines obesogens and how they impair hormone regulation like leptin and insulin.
  6. Janesick A, Blumberg B. “Obesogens: An emerging threat to public health.” American Journal of Obstetrics and Gynecology. 2016. Discusses endocrine disruption from environmental toxins, and their effects on fat storage and metabolic dysfunction.
  7. Bosch G, et al. “Mislabeling in pet foods: Identification of meat species by DNA analysis.” Journal of Animal Science, 2016. Confirms mislabeling in commercial dog food products, often not matching the stated ingredients.
  8. Gupta RC, et al. “Veterinary Toxicology.” 3rd edition. 2018. Details about preservatives, dyes, and contaminants found in pet foods that may disrupt hormones and metabolism.
  9. Overall KL. “Manual of Clinical Behavioral Medicine for Dogs and Cats.” 2013. Shows how stress (e.g., from extreme routines or calorie restriction) elevates cortisol and impairs weight loss.
  10. Kealy RD, et al. “Effects of diet restriction on life span and age-related changes in dogs.” Journal of the American Veterinary Medical Association. 2002. While moderate diet control helps, extreme calorie restriction can cause adverse health outcomes and joint issues.
  11. Lopez-Plaza B, et al. “Effect of conjugated linoleic acid on body composition and lipid profile: A systematic review and meta-analysis.” Clinical Nutrition, 2013. CLA reduces body fat and improves lean mass in animals and humans.
  12. Hand MS, Thatcher CD, et al. “Small Animal Clinical Nutrition.” 5th Edition. L-carnitine helps dogs utilize fat for energy and may aid in canine weight control.
  13. Williams CA, et al. “Taraxacum officinale (dandelion): A review of its traditional uses, phytochemistry, and pharmacology.” Journal of Ethnopharmacology, 1996. Known for diuretic and detoxifying effects, which can support weight loss indirectly.
  14. Ambati RR, et al. “Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications.” Marine Drugs, 2014. Astaxanthin is a potent antioxidant with strong anti-inflammatory benefits that may aid metabolism.
  15. Neelakantan N, et al. “Effect of fenugreek on glycemia and lipids: A meta-analysis.” Journal of Ethnopharmacology, 2014. Fenugreek helps regulate blood sugar and may aid in weight management by improving metabolism.
  16. Manach C, et al. “Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies.” American Journal of Clinical Nutrition, 2005. Highlights general absorption challenges of flavonoids—key reason for selecting bioavailable versions like Quercetin, Fisetin, and Luteolin.